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KMID : 1188320170110030377
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Gut and Liver
2017 Volume.11 No. 3 p.377 ~ p.382
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Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett’s Esophagus
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Lee Shou Wu
Lien Han Chung
Lee Teng Yu
Tung Chun Fang
Yeh Hong Zen
Chang Chi Sen
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Abstract
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Background/Aims: The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett’s esophagus (BE) in a Chinese population.
Methods: Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/obesity group (body mass index ≥25 mg/m2) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women).
Results: Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese.
Conclusions: Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases.
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KEYWORD
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Barrett esophagus, Gastroesophageal reflux, Obesity
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